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Promising news for Osteoporosis sufferers ( April 2007 )
Wed 02-5-2007
Major study finds that there is a new drug that significantly strengthens bones, and patients need to take it only once a year through IV drip for only 15 minutes.
Experts Speak Out: Once-a-Year Injection for Osteoporosis
Some Call New Treatment for Brittle Bone Disease a Breakthrough; Others Note Potential Heart Danger
A new option in the treatment of osteoporosis could one day change the way many of the 10 million Americans living with the bone-weakening condition are treated by doctors.
Research published in the current issue of the New England Journal of Medicine shows that a drug called Zometa (also known as Reclast), which is currently used in the treatment of metastatic bone cancer, also prevents bone loss through osteoporosis.
Patients taking the drug in the trial experienced a 70 percent reduced risk of fractures to the vertebrae, a 41 percent reduced risk of hip fracture and an overall improvement in bone density.
But what really sets the treatment apart from current options is the fact that it's a 15-minute, once-a-year IV procedure — a tempting prospect for many patients who cannot stomach the oral medications that are currently available.
But the treatment may come with risks as well; some of the patients taking the treatment experienced atrial fibrillation — an abnormal, potentially dangerous heart rhythm disorder.
Here's what experts had to say about the possible benefits — and side effects — of this possible future treatment:
Dr. Steven Cummings
Senior Author
Emeritus Professor of Medicine and Epidemiology
University of California at San Francisco San Francisco, Calif.: Only about one-third of patients continue to take oral treatments as long as one year. Giving one infusion a year guarantees compliance which, in turn, increases the effectiveness of treatment -- like an airbag instead of seat belts.
Dr. C. Conrad Johnston Jr.
Distinguished Professor of Medicine
Indiana University School of Medicine
Indianapolis, Ind. This clinical trial of zolendronic acid demonstrates very good reduction in fracture risk with relatively few side effects. Most important, this therapeutic approach could significantly reduce the poor adherence found with oral agents. It is an important addition to our armamentarium to fight osteoporosis.
Dr. Brian William Walsh
Director, Division of Surgical Gynecology
Brigham and Women's Hospital
Boston, Mass : An excellent study — well designed, adequately powered, showing statistically and clinically significant reductions in fracture rates. [Reclast] is potentially a breakthrough for the treatment of osteoporosis.
Dr. Robert R. Recker
Director
Osteoporosis Research Center
Creighton University School of Medicine
Omaha, Neb. The safety data show a minor concern regarding atrial fibrillation. This is not a major concern, since there was no significant increase in mortality or morbidity. More studies are needed to discover the mechanism of the association. The association could have occurred by chance.
Dr. Edward S. Leib
Director, Osteoporosis Center
Fletcher Allen Health Care
Burlington, Vt. Although there is not a clear reason why there is an increase in cardiac findings, especially atrial fibrillation, this is of concern and may require more evaluation, including animal studies of cardiac toxicity. This might affect the FDA's interest in approving this for therapy.
Dr. Robert Yood
Chief of Rheumatology
Fallon Clinic
Worcester, Mass.Compliance with oral bisphosphonates is poor; several studies show that by the end of one year, about half of patients have discontinued oral bisphosphonates. If compliance with yearly IV therapy is better, perhaps this drug will overall be more effective.
Dr. Javad Parvizi
Joint Specialist and Director of Orthopaedic Research
Rothman Institute at Thomas Jefferson University Hospital
Philadelphia, Pa. I don't think we should anticipate FDA regulations, but if approved, the use of this medication should be reserved to a limited population without heart conditions and severe or refractory osteoporosis.
You can find further information on ABCNews.Com http://abcnews.go.com/search?searchtext=osteoporosis&type=
and www.osteofound.org
Please add extra information, if you find this treatment is available in your country, where available etc. especially in Pakistan. It is for humanity sake, and Allah (S) will bless you for that, Inshallah.
Length: 137
Rating: 4.70 (3 ratings)
Tags: Osteoporosis Treatment Zoledronic Acid New Pakistan Afghanistan Bangladesh India Muslim Arab Doctor Europe America Asia
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Dr Whiting on Calcium, Absorption, and Osteoporosis
For years, medical doctors have touted the benefit of taking calcium and perhaps a magnesium supplement to slow down the progression of bone loss, a condition called osteoporosis. They have been reluctant however, to go so far as to say that these minerals can prevent or improve osteoporosis. This is because early studies indicated that taking calcium did not effectively increase bone density in menopausal and post-menopausal women. Recent studies however show that osteoporosis and bone loss can indeed be controlled and even reversed by the right combination of calcium, magnesium and select trace minerals. Studies conducted on osteoporosis and bone loss patients at the University of California at San Diego, have shown that when calcium and magnesium are combined with the right ratio of the trace minerals boron, manganese, copper, zinc and most recently, strontium, the return of calcium ions to bone tissue accelerates as much as ten-fold. Further, the calcium and magnesium used for osteoporosis and bone loss must be an acidified, chelated form for maximum absorption. Studies repeatedly show that a combination of citrates and malates provide the best absorption to combat bone loss and clinical osteoporosis. Alternatives to potentially dangerous drugs for osteoporosis include the right forms of calcium together with key trace minerals such as zinc, copper, manganese and strontium.
Length: 468
Rating: 5.00 (41 ratings)
Tags: Dr Whiting doctor healthyinformation.com health diet nutrition natural cure bone loss calcium absorption
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Osteoporosis
Helen Pensanti, MD discusses the treatment and prevention of osteoporosis ..... naturally.
Length: 275
Rating: 3.70 (3 ratings)
Tags: Women's Health Osteoporosis
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